Doug Treco, PhD, was a co-founder of Ra Pharmaceuticals, Inc. in 2008 and served as Chief Executive Officer and a member of the Board of Directors from its inception until its acquisition by UCB in April 2020. Previously, he was an Entrepreneur-in-Residence at Morgenthaler Ventures from January 2008 to May 2014. In 1988, he co-founded Transkaryotic Therapies Inc. (TKT), a multi-platform biopharmaceutical company developing protein and gene therapy products, which was acquired by Shire Pharmaceuticals Group plc in 2005. Dr. Treco was a Visiting Scientist in the Department of Molecular Biology at Massachusetts General Hospital and a Lecturer in Genetics at Harvard Medical School from 2004 to 2007. He received his Ph.D. in Biochemistry and Molecular Biology from the State University of New York at Stony Brook and performed postdoctoral studies at the Salk Institute for Biological Studies and Massachusetts General Hospital.
Adeline is an associate at Lightstone Singapore PTE. LTD. where she supports the team in evaluating new investment opportunities in the biopharmaceutical and medical device sectors.
Adeline was awarded the National Science Scholarship from the Agency for Science, Technology and Research (A*STAR) and received her B.Sc. from the University of Illinois, Urbana Champaign and her Ph.D. in Microbiology from Washington University, St Louis. Prior to joining Lightstone, Adeline was at A*STAR managing strategic research collaborations with industrial partners in the life sciences sector.
Hong I. Wan, Ph.D. is president, chief executive officer and co-founder of Tallac Therapeutics. Previously as chief scientific officer and a member of the founding management at ALX Oncology, she led the team to advance ALX148, a best-in-class myeloid checkpoint inhibitor, for multiple tumor indications. Prior to ALX Oncology, Dr. Wan held various leadership positions at Pfizer and Wyeth Research, where she was responsible for the early development and translational medicine strategy and execution across various therapeutic areas. Dr. Wan started her career at Renovis where she led discovery programs in neuroinflammation.
Dr. Pons currently serves as the President and Chief Executive Officer of ALX Oncology. He previously served as Chief Scientific Officer and site head of Rinat (Pfizer), where he was responsible for portfolio delivery from idea to clinical development. He implemented the vision of a company unit following biology across therapeutic areas while generating advanced antibody technologies and turned Rinat into the center of cancer immunology for Pfizer. Dr. Pons is an inventor of fremanezumab, which was approved by the FDA in 2018, as well as two other antibodies in late-stage clinical development and has advanced nine additional antibodies into human trials in multiple therapeutic areas. As Senior Vice President of R&D, he was a member of Pfizer’s World R&D Leadership Team. Before Pfizer, Dr. Pons created and led Rinat’s protein engineering group and was a scientist at Chiron.
Dr. Molineaux is the co-founder, President and CEO of Calithera Biosciences, a start-up company that commenced operations in June of 2010. Prior to starting Calithera, Dr. Molineaux was a co-founder of Proteolix and served as the CSO for two years before becoming President and CEO of the company. Proteolix was acquired by Onyx Pharmaceuticals in November 2009. Prior to joining Proteolix, Dr. Molineaux was Vice President of Biology at Rigel Pharmaceuticals from 2000 to 2003. Before that, she was Vice President of Biology at Praelux, and from 1994 through 1999, Dr. Molineaux served as Vice President of Drug Development at Praecis Pharmaceuticals. From 1989 until 1994 she was a scientist in the immunology group at Merck, in Rahway, NJ.
Wen Qi is a Vice President at Lightstone Singapore Pte,Ltd., where she evaluates new investment opportunities in the biopharmaceutical and medical device sectors out of the firm’s Singapore office.
Wen Qi attained her B.Sc. in Molecular and Cellular Biology at Johns Hopkins University, and her PhD in Immunology at Stanford University under the guidance of Professor Gerald Crabtree, a Howard Hughes Medical Institutes investigator. She was also the recipient of the National Science Scholarship from the Agency for Science, Technology and Research (A*STAR) Singapore. While at Stanford, she enrolled in the Program in Innovation and Entrepreneurship at the Stanford School of Business where she learned business fundamentals and had hands-on experience at developing an idea to business plan. Since moving to Singapore, Wen Qi has been actively involved in the Executive Committee of Biotech Connection Singapore, which aims to promote the life science entrepreneurship eco-system in Singapore by providing a platform for innovators, academics, and investors to come together.
Caroline joined Lightstone Ventures in 2017 and evaluates new investment opportunities in the biopharmaceutical and medical device sectors out of the firm’s Dublin office.
Caroline has over 10 years’ operational experience in the pharmaceutical industry. Caroline spent 9 years at Bayer Healthcare, most recently serving on the board of senior management of Bayer Ltd. Ireland as head of market access, pricing and reimbursement. During her time in pharma she held a number of operational roles, predominantly focused on oncology, such as product management, strategic marketing, business development and regulatory affairs. Prior to Lightstone, and following completion of her BioInnovate fellowship in 2013, she co-led R&D on a device targeting Acute Pancreatitis and was subsequently involved in early pre-clinical, strategic clinical and commercial development at Vetex Medical..
She currently serves as a director on the board of Catamaran Bio Ltd. and as observer to the board of Carrick Therapeutics, Cerevance, and FIRE-1. She also previously served on the board of ALX Oncology. She is a member of the BioInnovate Ireland Board of advisors.
Ken is currently the CEO of Lightstone Singapore Pte, Ltd.
Previously Ken was a consultant to the life science industry. Most recently he was a senior partner and head of the European Life Sciences Practice at L.E.K. Consulting LLP. Prior to that he was a partner in the pharmaceutical practice at Booz-Allen & Hamiliton. Ken was also the founding partner and head of the European practice at The Wilkerson Group Ltd. Ken’s operating experience in discovery includes management roles at Cooper Life Sciences (to include Technicon), Becton Dickinson and Bethesda Research Labs.
Ken has served as a Board member of both public and private life science companies in Europe and the U.S. to include Intercept Pharmaceuticals Inc., Kailos Genetics and Orchid Biosciences.
During his academic career Ken authored more than 50 articles on the role of the cell surface in cell division.
Chris was a Founding Partner of Lightstone Ventures and is currently a Special Partner. He focuses on biopharmaceutical investments out of the firm’s Boulder, CO, office. Chris joined Morgenthaler in 2001 and serves as a General Partner. His signature deals include Avidia (acquired by Amgen in 2006), Threshold (NASDAQ: THLD), Morphotek (acquired by Easai in 2007), FoldRx (acquired by Pfizer in 2010), and Nimbus Therapeutics/Apollo (partially acquired by Gilead in 2015). He serves on the boards of Adastra Pharmaceuticals, and previously on Nimbus. Chris brings to Lightstone more than 20 years of operations experience, having served as CEO and President of Ribozyme Pharmaceuticals (a/k/a Sirna Therapeutics; acquired by Merck for $1.2B), Senior Vice President of Research at SmithKline Beecham, Vice President of Discovery Research at The Upjohn Company, and President of Colorado State University.
Chris is a recognized thought leader in the field of biotechnology. He received an honorary Doctor of Law degree from Cornell College in 1983, the Outstanding Research of Year Award from the International Society of Quantum Biology in 1981, the W. E. Upjohn Award for contributions in biotechnology in 1988, and a Lifetime Achievement Award in 2003 from the Colorado Biosciences Association.
Jean is a General Partner of Lightstone Ventures. She focuses on biopharmaceutical and medical device investments out of the firm’s Boston office, where she also serves as a General Partner of Advanced Technology Ventures (ATV). Her representative investments include Acceleron Pharma (NASDAQ: XLRN), Calithera Biosciences (NASDAQ: CALA), Cyteir Therapeutics, Disarm Therapeutics (acquired by Eli Lilly), Flex Pharma (NASDAQ: FLKS), Five Prime Therapeutics (NASDAQ: FPRX), Gemini Therapeutics, Hypnion (acquired by Eli Lilly), Locanabio Therapeutics, Portola Pharmaceuticals (NASDAQ: PTLA), Proteolix (acquired by Onyx Pharmaceuticals), Tizona Therapetics (acquired by Gilead), Verastem (NASDAQ: VSTM), and Zeltiq Aesthetics (NASDAQ: ZLTQ).
Jean has been featured on the Forbes Midas List and was previously a member of the Scientific Advisory Board for the Massachusetts Life Sciences Center. Prior to LSV and ATV, Jean worked for BancBoston Ventures and led its life sciences investments in Neurometrix (NASDAQ:NURO), Ironwood Pharmaceuticals (NASDAQ: IRWD), NuGenesis Technologies (acquired by Waters) and Syntonix Pharmaceuticals (acquired by Biogen/Idec).
She has been in the biopharmaceutical industry for over 30 years, including 10 years with Genzyme Corporation, where she held a variety of operational roles in marketing, product development, and business development, including Vice President of Global Sales and Marketing. She also was Vice President and Founder of Genzyme’s Tissue Repair Division. Previously, Jean spent six years working in chemistry and bioresearch.
Lightstone Ventures is committed to advancing a more diverse, equitable & inclusive venture capital ecosystem. As part of this commitment, we have signed the #VCHumanCapital Pledge to submit our firm’s demographic and talent management details to support the industry’s data collection and tracking efforts. As an industry, we can only improve what we measure, and the 2020 VC Human Capital Survey—powered by NVCA, Venture Forward, and Deloitte—is a critical component to tracking and measuring our progress.
Learn more about the survey and see the full list of VC firms who have pledged their participation here: https://nvca.org/nvca-and-venture-forward-vchumancapital-pledge